Abstract
L-N5-(1-Hydroxyiminoethyl)-ornithine (L-NHIO) and L-N6-(1-hydroxyiminoethyl)-lysine (L-NHIL) were synthesized and tested as potential intermediates in the mechanism-based inactivation of nitric oxide synthase (NOS) by L-N5-iminoethylornithine (L-NIO) and L-N6-iminoethyllysine (L-NIL). Although these compounds were determined to be competitive inhibitors, mechanism-based inactivation was not observed.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Binding, Competitive
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Enzyme Activation
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Enzyme Inhibitors / pharmacology
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Hydroxylation
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Lysine / analogs & derivatives*
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Lysine / pharmacology
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Nitric Oxide Synthase / antagonists & inhibitors
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Nitric Oxide Synthase / chemistry
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Nitric Oxide Synthase / metabolism*
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Ornithine / analogs & derivatives*
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Ornithine / pharmacology
Substances
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Enzyme Inhibitors
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N(6)-(1-iminoethyl)lysine
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N(G)-iminoethylornithine
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Ornithine
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Nitric Oxide Synthase
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Lysine